The BCG vaccination is to prevent tuberculosis which is still commonplace in the world although not so much in U.S. but it is still present. That's all known and nicey nice since most Americans don't have it while many Asians do so maybe they ought to get cracking with BCG over there.
Tuberculosis was once known as consumption and you have likely seen that in your readings of just about any old timey thing since that's what killed Doc Holliday and a whole lot of other people in olden times. (WIKI: Doc Holliday)
So they've done a good job trying to wipe out tuberculosis with this BCG vaccine but the researchers believed it may have more therapeutic potential. (Science Daily: Potential mechanism for BCG vaccine reversal of type 1 diabetes)
And you thought riding that bucking bronco at the cowboy bar was wild, this BCG looks like it goes after two of the worst scourges we know.
Interim results from a FDA-approved clinical trial testing the generic vaccine bacillus Calmette-Guérin (BCG) to reverse advanced type 1 diabetes are being presented at the 75th Scientific Sessions of the American Diabetes Association. The data demonstrate a potential new mechanism by which the BCG vaccine may restore the proper immune response to the insulin-secreting islet cells of the pancreas. Presented by Denise Faustman, MD, PhD, director of the Massachusetts General Hospital Immunobiology Laboratory and principal investigator of the trial, the findings suggest that BCG may induce a permanent increase in expression of genes that restore the beneficial regulatory T cells (Tregs) that prevent the immune system from attacking the body's own tissue. The results are being presented on Saturday, June 10.
- SD
SD won't make the plug for feminism but I will. Dr Denise Faustman was P.I. for this research and that's not Private Investigator but Primary Investigator which makes you a god / goddess in the scientific world since it most likely means you came up with the idea and wrote the funding proposal which got it rolling. Women do blowaway things in science but it's hardly ever recognized; it's not much recognized with men either so that's the state of things but you can see it held her back in no way at all.
Faustman's research team was the first group to document reversal of advanced type 1 diabetes in mice and subsequently completed a successful phase I human clinical trial of BCG vaccination. The five-year, 150-person, phase II trial is investigating whether repeat BCG vaccination can clinically improve type 1 diabetes in adults with existing disease and is almost fully enrolled. Details on the trial and enrollment are available at: https://clinicaltrials.gov/ct2/show/NCT02081326.
Long-term follow-up data from the phase I trial will be published later this year. The phase II trial is entirely funded by private philanthropy from individuals and family foundations.
- SD
That was the conclusion of the paper and the rest remains for the interested student but that finale shows us Dr Faustman isn't talking about a hypothesis but research which has just about completed the second phase of the human clinical trials so it appears to be on the verge of becoming available to the general public.
Imagine that ... a two-banger vaccine and they are some bloody great bangs, I must say.
For the most unusual twist, check out who paid for it.
Tuberculosis was once known as consumption and you have likely seen that in your readings of just about any old timey thing since that's what killed Doc Holliday and a whole lot of other people in olden times. (WIKI: Doc Holliday)
So they've done a good job trying to wipe out tuberculosis with this BCG vaccine but the researchers believed it may have more therapeutic potential. (Science Daily: Potential mechanism for BCG vaccine reversal of type 1 diabetes)
And you thought riding that bucking bronco at the cowboy bar was wild, this BCG looks like it goes after two of the worst scourges we know.
Interim results from a FDA-approved clinical trial testing the generic vaccine bacillus Calmette-Guérin (BCG) to reverse advanced type 1 diabetes are being presented at the 75th Scientific Sessions of the American Diabetes Association. The data demonstrate a potential new mechanism by which the BCG vaccine may restore the proper immune response to the insulin-secreting islet cells of the pancreas. Presented by Denise Faustman, MD, PhD, director of the Massachusetts General Hospital Immunobiology Laboratory and principal investigator of the trial, the findings suggest that BCG may induce a permanent increase in expression of genes that restore the beneficial regulatory T cells (Tregs) that prevent the immune system from attacking the body's own tissue. The results are being presented on Saturday, June 10.
- SD
SD won't make the plug for feminism but I will. Dr Denise Faustman was P.I. for this research and that's not Private Investigator but Primary Investigator which makes you a god / goddess in the scientific world since it most likely means you came up with the idea and wrote the funding proposal which got it rolling. Women do blowaway things in science but it's hardly ever recognized; it's not much recognized with men either so that's the state of things but you can see it held her back in no way at all.
Faustman's research team was the first group to document reversal of advanced type 1 diabetes in mice and subsequently completed a successful phase I human clinical trial of BCG vaccination. The five-year, 150-person, phase II trial is investigating whether repeat BCG vaccination can clinically improve type 1 diabetes in adults with existing disease and is almost fully enrolled. Details on the trial and enrollment are available at: https://clinicaltrials.gov/ct2/show/NCT02081326.
Long-term follow-up data from the phase I trial will be published later this year. The phase II trial is entirely funded by private philanthropy from individuals and family foundations.
- SD
That was the conclusion of the paper and the rest remains for the interested student but that finale shows us Dr Faustman isn't talking about a hypothesis but research which has just about completed the second phase of the human clinical trials so it appears to be on the verge of becoming available to the general public.
Imagine that ... a two-banger vaccine and they are some bloody great bangs, I must say.
For the most unusual twist, check out who paid for it.
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