No-one in the Rockhouse has diabetes or any apparent indication it's coming but we have encountered enough people with trouble with the disease to know it's more common than we realize. Therefore, we have interest in anything which improves the processing of insulin and this research appears to offer such improvement. (Science Daily: Insulin resistance reversed by removal of protein)
The article goes some distance to describe how Gal3 protein works but we don't need that level of sophistication. Continue with the article link as you will.
"This study puts Gal3 on the map for insulin resistance and diabetes in mouse model," said Olefsky, associate dean for scientific affairs and senior author of the study. "Our findings suggest that Gal3 inhibition in people could be an effective anti-diabetic approach."
- Science Daily
We just care that elimination of Gal3 works and that seems to be true based on this new research.
Here's a summary of what they did, as opposed to the mechanics of how Gal3 does what it does.
By removing the protein galectin-3 (Gal3), a team of investigators led by University of California School of Medicine researchers were able to reverse diabetic insulin resistance and glucose intolerance in mouse models of obesity and diabetes.
By binding to insulin receptors on cells, Gal3 prevents insulin from attaching to the receptors resulting in cellular insulin resistance. The team led by Jerrold Olefsky, MD, professor of medicine in the Division of Endocrinology and Metabolism at UC San Diego School of Medicine, showed that by genetically removing Gal3 or using pharmaceutical inhibitors to target it, insulin sensitivity and glucose tolerance could be returned to normal, even among older mice. However, obesity remained unchanged.
The article goes some distance to describe how Gal3 protein works but we don't need that level of sophistication. Continue with the article link as you will.
"This study puts Gal3 on the map for insulin resistance and diabetes in mouse model," said Olefsky, associate dean for scientific affairs and senior author of the study. "Our findings suggest that Gal3 inhibition in people could be an effective anti-diabetic approach."
- Science Daily
We just care that elimination of Gal3 works and that seems to be true based on this new research.
Here's a summary of what they did, as opposed to the mechanics of how Gal3 does what it does.
By removing the protein galectin-3 (Gal3), a team of investigators led by University of California School of Medicine researchers were able to reverse diabetic insulin resistance and glucose intolerance in mouse models of obesity and diabetes.
By binding to insulin receptors on cells, Gal3 prevents insulin from attaching to the receptors resulting in cellular insulin resistance. The team led by Jerrold Olefsky, MD, professor of medicine in the Division of Endocrinology and Metabolism at UC San Diego School of Medicine, showed that by genetically removing Gal3 or using pharmaceutical inhibitors to target it, insulin sensitivity and glucose tolerance could be returned to normal, even among older mice. However, obesity remained unchanged.
- Science Daily
It's too early to talk to your doctor about this since you will have to find one seriously spritely medico to locate one who reads papers the first day they're published. They make up a highly eager bunch that way and they may actually have read the article but they probably would not talk to patients until it gets some more road testing.
We're satisfied the research got precisely the amount of road testing it needed to satisfy the protocol for the experiment but that standard is not the same as that which is needed before a doctor will take it into the clinic for patients. It's indicative of a strongly positive direction in the research and that's the reason for passing it along here.
Note: there's reticence in the Rockhouse regarding 'medical breakthroughs,'' etc since we're not doctors and something isn't a medical breakthrough unless doctors are saying it. We're leery of the possibility of anything being taken as medical advice and consequently the content may be more cautious than it might otherwise be.
In any case, we have seen severe punishments from diabetes and it's highly damn good to see anything which may defend better against that.
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