Friday, September 9, 2016

Brains Are More Complicated than Previously Known

That's probably not a surprise to you when new aspects of its function turn up frequently but this research goes specifically toward synaptic responses.  (Science Daily:  Brain connections are more sophisticated than thought)

The article makes clear the preference in targeting psychoactive drugs at synaptic performance but not specifically mentioned was the class of serotonin reuptake inhibitors (SSRI), the same class for Prozac, Paxil, and a whole array of ridiculously-overpriced drugs available by prescription.

Note:  these types of 'happy drugs' have created a type of soma for elitists who can rationalize, well, at least we don't use that Oxycontin, that 'hillbilly heroin.'  That theme is an article or an encyclopedia by itself.


The discovery from the latest research is that Excitatory and Inhibitory proteins related to synaptic response were not well-understood from the Inhibitory side.  The research revealed a great many Inhibitory proteins than were previously known.

The implications in the context of SSRI drugs seems straightforward.  If the objective is to reduce manic behavior then it seems better understanding of the newly-discovered proteins is important.  The manic / depressive cycle seems the general problem to solve so it therefore seems research along those lines could be fruitful.

There is interest because I went through the psychiatric ringer with SSRI drugs and pronounce the lot of them 'bloody rubbish' but, as noted in the WIKI, shrinks really don't understand how they work anyway so your results may be different.  (WIKI: Selective serotonin reuptake inhibitor)


One unusual note is Edward Gray was the first to note the bimodal state of synapses in terms of being in a process of excitation or inhibition but I looked and his name has almost disappeared.  There was an Edward Grey who achieved fame for other things but Gray's research in 1959 may well have been the seminal work regarding all the research which followed it.  How unfortunate he doesn't seem to have much recognition for that.  Here's a reference in Quantum Brain Dynamics and Consciousness: An Introduction by Mari Jabu.

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