Sometimes it's easiest to create a number of draft articles and then review them in sum with the thinking as with "Weird Science," "What would you little maniacs like to play with first" and that leads to the thinking endless life would be a good pick. (Science Daily: Natural compound reduces signs of aging in healthy mice)
Aging means the body's systems starting becoming less efficient and effective in providing services the body needs and the discover is a naturally-occurring compound can slow that decline. Any reduction in that decline means we live longer ... but the population in question is one of mice.
"We have shown a way to slow the physiologic decline that we see in aging mice," said Shin-ichiro Imai, MD, PhD, a professor of developmental biology and of medicine. " This means older mice have metabolism and energy levels resembling that of younger mice. Since human cells rely on this same energy production process, we are hopeful this will translate into a method to help people remain healthier as they age."
"When we give NMN to the young mice, they do not become healthier young mice," Yoshino said. "NMN supplementation has no effect in the young mice because they are still making plenty of their own NMN. We suspect that the increase in inflammation that happens with aging reduces the body's ability to make NMN and, by extension, NAD."
"Some tumor cells are known to have a higher capability to synthesize NAD, so we were concerned that giving NMN might increase cancer incidence," Imai said. "But we have not seen any differences in cancer rates between the groups."
Aging means the body's systems starting becoming less efficient and effective in providing services the body needs and the discover is a naturally-occurring compound can slow that decline. Any reduction in that decline means we live longer ... but the population in question is one of mice.
"We have shown a way to slow the physiologic decline that we see in aging mice," said Shin-ichiro Imai, MD, PhD, a professor of developmental biology and of medicine. " This means older mice have metabolism and energy levels resembling that of younger mice. Since human cells rely on this same energy production process, we are hopeful this will translate into a method to help people remain healthier as they age."
- Science Daily
That statement clarifies the observation insofar as we may not necessarily live longer but potentially will live better. In further commentary, they reveal the test compound doesn't do anything with young mice and only has an effect for older ones.
The researchers found a variety of beneficial effects of NMN supplementation, including in skeletal muscle, liver function, bone density, eye function, insulin sensitivity, immune function, body weight and physical activity levels. But these benefits were seen exclusively in older mice.
"When we give NMN to the young mice, they do not become healthier young mice," Yoshino said. "NMN supplementation has no effect in the young mice because they are still making plenty of their own NMN. We suspect that the increase in inflammation that happens with aging reduces the body's ability to make NMN and, by extension, NAD."
- Science Daily
The research seems obvious in retrospect since they looked at what chemicals the body doesn't make so well as it ages and they gave it some. That seems obvious now but it wasn't so much until they wrote the paper.
The scientists aren't so much pursuing eternal life as something of a NASCAR late-life pit stop in which we can top up the fuel tank, get fresh tires, etc.
During the long-term NMN study in healthy mice, Imai also said they monitored the animals for any potential increase in cancer development as a result of NMN administration.
"Some tumor cells are known to have a higher capability to synthesize NAD, so we were concerned that giving NMN might increase cancer incidence," Imai said. "But we have not seen any differences in cancer rates between the groups."
- Science Daily
It's sounding like there's little in the way of any negative effect but really why would there be when the body naturally makes the stuff anyway but loses the ability to make it and the science gives that back so it appears this may not so much extend life but rather it improves the quality of it. Before you get too disappointed, young Life Surfer, that's one hell of a good thing.
As life progresses, it's not that everything breaks at once since it's not like that and anything which can help lagging 'components' keep up with the party could make for one grand improvement. It appears that comes.
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